GcMaf 500ng + LPS

What does GcMAF + LPS do?

• GcMAF (deglycosylated vitamin D-binding protein) activates macrophages to the M1 type, leading to:

  • Increased phagocytosis (clearance of pathogens and cells) nature.com+15mdpi.com+15pmc.ncbi.nlm.nih.gov+15

  • Production of pro-inflammatory signals such as TNF-α and iNOS en.wikipedia.org+13mdpi.com+13mdpi.com+13

• LPS (lipopolysaccharide) activates macrophages through the TLR4 pattern, resulting in a potent inflammatory response and M1 polarization.

• Combination of GcMAF + LPS:

  • In experiments (e.g., on mouse macrophages), the combination has been shown to lead to greater increases in macrophage phagocytosis than either of the two individually researchgate.net+15sciencedirect.com+15jneuropsychiatry.org+15.

  • GcMAF alone appears to provide more targeted activation without the excessive production of harmful cytokines (such as TNF-α and NO) that occur with LPS en.wikipedia.org+13researchgate.net+13researchgate.net+13.

Research on GcMAF + LPS

1. In vitro study with peritoneal macrophages

   • Comparison GcMAF-RF and LPS showed that GcMAF induces polarized M1 macrophage activity with fewer inflammatory markers than LPS en.wikipedia.org+2researchgate.net+2cdn.clinicaltrials.gov+2pmc.ncbi.nlm.nih.gov.

2. Macrophage polarization and M1/M2 reversal

   • Studies show that GcMAF converts M2 macrophages (mostly inhibitory) to active M1 type. The addition of LPS further enhances phagocytosis activity .

3. Notable difference from LPS alone

   • No excessive NO or TNF-α production is seen in GcMAF, unlike LPS.

Conclusion

• GcMAF + LPS potently activates macrophages to the M1 system, with increased phagocytosis.

• LPS alone can lead to excess inflammation (NO, TNF-α).

• GcMAF alone provides targeted macrophage activation without a strong inflammatory response.

• Combination is experimental – mainly in laboratory studies, not in clinical setting.

Notice:
All of these findings are based on laboratory studies (cells or animal models). There is (to our knowledge) no clinical research describing combined efficacy in humans. Moreover, some GcMAF studies have been discredited or withdrawn jneuropsychiatry.org+12en.wikipedia.org+12pmc.ncbi.nlm.nih.gov+12researchgate.net+1it.wikipedia.org+1.